AbstractSee Finger (doi: ) for a scientific commentary on this article.Abnormal eating behaviour and metabolic parameters including insulin resistance, dyslipidaemia and body mass index are increasingly recognized as important components of neurodegenerative disease and may contribute to survival. It has previously been established that behavioural variant frontotemporal dementia is associated with abnormal eating behaviour characterized by increased sweet preference. In this study, it was hypothesized that behavioural variant frontotemporal dementia might also be associated with altered energy expenditure. A cohort of 19 patients with behavioural variant frontotemporal dementia, 13 with Alzheimer’s disease and 16 (age- and sex-matched) healthy control subjects were studied using Actiheart devices (CamNtech) to assess resting and stressed heart rate. Actiheart devices were fitted for 7 days to measure sleeping heart rate, activity levels, and resting, active and total energy expenditure. Using high resolution structural magnetic resonance imaging the neural correlates of increased resting heart rate were investigated including cortical thickness and region of interest analyses. In behavioural variant frontotemporal dementia, resting ( P = 0.001), stressed ( P = 0.037) and sleeping heart rate ( P = 0.038) were increased compared to control subjects, and resting heart rate ( P = 0.020) compared to Alzheimer disease patients.
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Draws an ellipse with the specified semimajor and semiminor axes,centered at ( x, y). Parameters: x - the x-coordinate of the center of the ellipse y - the y-coordinate of the center of the ellipse semiMajorAxis - is the semimajor axis of the ellipse semiMinorAxis - is the semiminor axis of the ellipse Throws: - if either semiMajorAxisor semiMinorAxis is negative - if any argument is either NaN or infinite. filledEllipse public static void filledEllipse(double x,double y,double semiMajorAxis,double semiMinorAxis). Draws a filled ellipse with the specified semimajor and semiminor axes,centered at ( x, y). Parameters: x - the x-coordinate of the center of the ellipse y - the y-coordinate of the center of the ellipse semiMajorAxis - is the semimajor axis of the ellipse semiMinorAxis - is the semiminor axis of the ellipse Throws: - if either semiMajorAxisor semiMinorAxis is negative - if any argument is either NaN or infinite.
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